In order to define the role of alcohol in cAMP-induced insulin release, the two agents were infused into the pancreas or liver of normal dogs separately or in combination. Blood levels of insulin and glucose were measured in the portal vein. CAMP infusion in the pancreatic artery provoked a greater early insulin response than did a similar infusion into the portal vein when glycemic levels were comparable. The addition of alcohol suppressed insulin response to intrapancreatic cAMP. Alcohol in the absence of the stimulus failed to suppress insulin below basal levels. It is concluded that pancreatic alcohol directly inhibits cAMP-related insulin release and that this is the mechanism by which glucagon-induced insulin release is blunted by alcohol. Glucose-induced release, which is potentiated by intravenous alcohol, apparently involves another mechanism.

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