Immunoreactive insulin was measured in the medium following incubation of isolated rat islets of Langerhans in different concentrations of propranolol and propranolol plus glucose. Pretreatment with propranolol (20 μg./ml.) prevented glucose (3 mg./ml.)-mediated insulin release. Propranolol alone in concentrations up to 25 μg./ml. did not cause insulin release; however, at 50 μg./ml. this drug had strong beta-cytotrophic activity.

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