Concentrations of tolbutamide from 0.25 to 4.0 mg. per milliliter were found to inhibit epinephrine-stimulated lipolysis in isolated fat cells of the rat. At a concentration of 1 mg. per milliliter, tolbutamide also inhibited lipolysis stimulated by ACTH or dibutyryl cyclic AMP. At the same concentration it failed to alter basal lipolysis, basal or epinephrine-stimulated cyclic AMP levels. Basal and epinephrine-stimulated adenylate cyclase and glycogen phosphorylase as well as binding of cyclic AMP to protein kinase were unaltered. These data are discussed in relation to the antilipolytic mechanism of tolbutamide.
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Original Contributions| January 01 1974
Antilipolytic Action of Tolbutamide in Isolated Fat Cells of the Rat
Donald O Allen, Ph.D.;
Elwood E Largis, Ph.D.;
Donald O Allen, Elwood E Largis, James Ashmore; Antilipolytic Action of Tolbutamide in Isolated Fat Cells of the Rat. Diabetes 1 January 1974; 23 (1): 51–54. https://doi.org/10.2337/diab.23.1.51
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