Sustained Insulin Release in Response to Intravenous Infusion of Insulin Releasing Polypeptide (IRP) in the Rat

A greatly elevated and sustained insulinemic response was evoked in cats by the intravenous infusion of a solution of IRP in glucose compared with that produced by glucose alone. Larger doses of IRP produced correspondingly greater increases in insulin release.

IRP enhanced glucose disposal up to a finite limit despite higher plasma insulin levels suggesting that there is a maximum rate of glucose disposal under conditions of intense insulin stimulation.