Streptozotocin (STZ)-diabetic rats regularly retained sodium (Na+), and tended to retain potassium (K+) as well, in response to insulin. Diabetic patients have also been reported to exhibit antinatriuresis and antikaliuresis early in the course of insulin therapy. Insulin-related Na+ retention can occur without a marked reduction in blood glucose level and does not appear to be attributable to preexisting Na+ depletion, mineralocorticoid effect, or suppression of glucosuria. The decrease in urinary Na+ excretion (UNaV) in the rats incident to insulin administration was appreciably greater than the decrease in chloride (Cl−) or water excretion. The significance of this observation is uncertain. It may be, in part, a consequence of the nephrotoxicity of STZ. Insulin-related Na+ retention may be closely related pathogenetically to the Na+ retention of refeeding and may reflect a direct renal action of insulin or, less likely, an alteration of renal tubular metabolism in response to insulin-mediated changes in systemic metabolism.
Skip Nav Destination
Original contribution| July 01 1975
Observations on Sodium Retention Related to Insulin Treatment of Experimental Diabetes
- Views Icon Views
- Share Icon Share
Stanley A Blumenthal; Observations on Sodium Retention Related to Insulin Treatment of Experimental Diabetes. Diabetes 1 July 1975; 24 (7): 645–649. https://doi.org/10.2337/diab.24.7.645
Download citation file: