The effects of tolbutamide infusion (1 gm. over forty minutes) on plasma pancreatic glucagon-like immunoreactivity (PGLI), serum insulin, and blood glucose were studied in six patients with chronic pancreatitis and six matched controls.asal PGLI levels were significantly higher in the patients, despite higher fasting glucose concentrations. Tolbutamide infusion had no significant effect on mean PGLI levels in controls but was associated with significant elevation in pancreatitis patients, despite higher circulating glucose levels in the latter. The data suggest that chronic calcific pancreatitis patients hypersecrete immunoreactive glucagon, possibly from a nonpancreatic source and that this immunocreactive material may be stimulated by sulfonylureas.
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Original Contributions|
September 01 1975
Immunoreactive Glucagon Responses to Intravenous Tolbutamide in Chronic Pancreatitis
W J Kalk, M.B.Ch.B., M.R.C.P.;
W J Kalk, M.B.Ch.B., M.R.C.P.
Endocrine and Diabetes Research Group, Department of Medicine University of Cape Town and Groote Schuur Hospital
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A I Vinik, M.D., F.C.P.;
A I Vinik, M.D., F.C.P.
Endocrine and Diabetes Research Group, Department of Medicine University of Cape Town and Groote Schuur Hospital
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M Paul;
M Paul
Endocrine and Diabetes Research Group, Department of Medicine University of Cape Town and Groote Schuur Hospital
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P Keller, Ph.D.;
P Keller, Ph.D.
Endocrine and Diabetes Research Group, Department of Medicine University of Cape Town and Groote Schuur Hospital
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W P U Jackson, M.A., M.D., F.R.C.P.
W P U Jackson, M.A., M.D., F.R.C.P.
Endocrine and Diabetes Research Group, Department of Medicine University of Cape Town and Groote Schuur Hospital
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Citation
W J Kalk, A I Vinik, M Paul, P Keller, W P U Jackson; Immunoreactive Glucagon Responses to Intravenous Tolbutamide in Chronic Pancreatitis. Diabetes 1 September 1975; 24 (9): 851–855. https://doi.org/10.2337/diab.24.9.851
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