The minor hemoglobins AIa, AIb, and AIc were studied in mice with either genetic or chemically induced diabetes. Hemoglobin AIc was elevated approximately twofold in all the phenotypically diabetic mice studied (C57BL/KsJ-db/db, C57BL/KsJ-ob/ob, C57BL7/6J-db/db, and alloxan- and streptozotocin-treated mice). Elevation of the hemoglobin Ale in C57BL/6J-db/db mice was of short duration, reflecting the transitory diabetes characteristic of these mice. The degree of increase of hemoglobin AIclevels was unrelated to severity of hyperglycemia, duration of diabetes, age of mouse, or body weight. It is not-known what factor(s) dictates the steady-state concentration of hemoglobin AIc.
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