Fasting blood glucose (FBG), serum immunoreactive insulin (IRI), plasma immunoreactive glucagon (IRG), body weight, and caloric intake were measured in long-term islet-isografted rats eight to 10 months following intraperitoneal islet transplantation in in age-matched, sham-operated, concurrently followed normal and diabetic controls. Islet recipients had normal body weights, but they were significantly polyphagic, hyperinsulinemic, and hyperglucagonemic when compared with normals. Fasting blood glucose levels were reduced by 10 per cent. Several factors may be related to the occurrence of these abnormalities in long-term islet-isografted rats, including (1) the mass of islets transplanted, (2) the age of donor tissue, (3) the heterotopic location of islet grafts, and (4) the lack of normal innervation of transplanted islet cells.
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Original Articles|
October 01 1976
Hyperinsulinemia and Hyperglucagonemia Following Pancreatic Islet Transplantation in Diabetic Rats
C J Weber, M.D.;
C J Weber, M.D.
Department of Surgery, Columbia University College of Physicians and Surgeons
New York, New York
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M A Hardy, M.D.;
M A Hardy, M.D.
Department of Surgery, Columbia University College of Physicians and Surgeons
New York, New York
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R L Lerner, M.D.;
R L Lerner, M.D.
Department of Surgery, Columbia University College of Physicians and Surgeons
New York, New York
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P Felig, M.D.;
P Felig, M.D.
Department of Surgery, Columbia University College of Physicians and Surgeons
New York, New York
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K Reemtsma, M.D.
K Reemtsma, M.D.
Department of Surgery, Columbia University College of Physicians and Surgeons
New York, New York
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1
Division of Endocrinology, U.S.C. School of Medicine, Los Angeles, California.
2
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Address reprint requests to Dr. Weber, Department of Surgery, Columbia University, College of Physicians and Surgeons, 630 West 168 Street, New York, New York 10032.
Citation
C J Weber, M A Hardy, R L Lerner, P Felig, K Reemtsma; Hyperinsulinemia and Hyperglucagonemia Following Pancreatic Islet Transplantation in Diabetic Rats. Diabetes 1 October 1976; 25 (10): 944–948. https://doi.org/10.2337/diab.25.10.944
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