Hemoglobin AIc concentration, fasting blood sugar, response to an oral glucose tolerance test, and skeletal muscle capillary basement membrane thickness were measured in diabetic patients. Hemoglobin AIc concentration correlates with both response to a glucose tolerance test (r = 0.82, p < 0.001) and fasting blood sugar (r = 0.62, p < 0.001). The correlation of hemoglobin AIc concentration with glucose tolerance is independent of fasting blood sugar concentration (partial r = 0.61, p < 0.005), whereas that of hemoglobin AIc with fasting blood sugar probably reflects the relationship between fasting blood sugar levels and glucose tolerance (partial r = 0.22, p < 0.05). Hemoglobin AIc levels do not correlate with basement membrane thickness (r = 0.15, p < 0.05).
Hemoglobin AIc as an indicator of the degree of glucose intolerance in diabetes
Ronald J Koenig, Charles M Peterson, Charle Kilo, Anthony Cerami, Joseph R Williamson; Hemoglobin AIc as an indicator of the degree of glucose intolerance in diabetes. Diabetes 1 March 1976; 25 (3): 230–232. https://doi.org/10.2337/diab.25.3.230
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