In eight brittle diabetics the insulin requirement increased during successful pregnancies from 35 to 64 U ./day (in 29 stable severe diabetics from 53 to 78 U./day). The within-day glycemie excursions were calculated as the mean of the three differences between four time points: fasting, one hour after breakfast, two hours after breakfast, and two hours after lunch. This parameter was constant throughout the pregnancy in nondiabetics (34-46 mg./100 ml.) and stable severe diabetics (55-72 mg./100 ml.). In brittle diabetics itdropped from 147 mg./100 ml. before the pregnancy and 153 mg/100 ml. at eight weeks to 85 mg./100 ml. at 36 weeks. The between-day variability was calculated as the mean glycemie difference between two successive days at the four points of time noted above. It was very low in nondiabetics (12-16 mg/lOO ml.) and much higher in stable diabetics (49-53 mg./100 ml.). In brittle diabetics it decreased from 127 mg./100 ml. before pregnancy and 120 mg./100 ml. at eight weeks to 46-55 mg./100 ml. at 24-36 weeks. This shows that brittleness substantially decreased in the second half of pregnancy.
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Original Articles|
October 01 1977
Brittle Diabetes in Pregnancy
Arye Lev-Ran, MD, PhD;
Arye Lev-Ran, MD, PhD
Central Endocrine Laboratory of the Sick Fund and the Diabetic Clinic, Beilinson Hospital, Departments of Obstetrics and Gynecology, Beilinson and Hasharon Hospitals
Petah-Tikva
Tel-Aviv University Medical School
Tel-Aviv, Israel
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Jack A Goldman, MD
Jack A Goldman, MD
Central Endocrine Laboratory of the Sick Fund and the Diabetic Clinic, Beilinson Hospital, Departments of Obstetrics and Gynecology, Beilinson and Hasharon Hospitals
Petah-Tikva
Tel-Aviv University Medical School
Tel-Aviv, Israel
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Diabetes 1977;26(10):926–930
Article history
Accepted:
May 17 1977
Citation
Arye Lev-Ran, Jack A Goldman; Brittle Diabetes in Pregnancy. Diabetes 1 October 1977; 26 (10): 926–930. https://doi.org/10.2337/diab.26.10.926
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