The glucagon-secreting potency of 22 amino acids was investigated in the rat isolated perfused pancreas. Arginine and the structurally related amino acids were the most potent A2-cell stimulators that induced a biphasic and sustained glucagon release. Dose-response curves were different for L(+) and D(+)arginine, and the suppressor effect of glucose on the response to L(+) arginine was not detected in the presence of D(+) arginine or homoarginine. Citrul-line was the only exception among the arginine-related amino acids; it displayed neither stimulatory nor inhibitory potency on glucagon release. The A2-cell response to D(+) amino acids and artificial analogues of arginine is a strong case for the theory of amino acid receptors' triggering the release of the hormone before (or in the absence of) further metabolism. The prominent rank of arginine and or ni thine among stimulatory amino acids and some other physiologic evidence suggest that A2-cell may play a regulatory role in the metabolism of ammonia by the liver.
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April 01 1977
Glucagon Secretion Induced by Natural and Artificial Amino Acids in the Perfused Rat Pancreas
Roger Assan, MD;
Roger Assan, MD
Department of Diabetology
Hôtel-Dieu, Paris, France
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Jean R Attali, MD;
Jean R Attali, MD
Department of Diabetology
Hôtel-Dieu, Paris, France
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Giuseppe Ballerio, MD;
Giuseppe Ballerio, MD
Department of Diabetology
Hôtel-Dieu, Paris, France
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Josette Boillot;
Josette Boillot
Department of Diabetology
Hôtel-Dieu, Paris, France
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Jean R Girard, PhD
Jean R Girard, PhD
Department of Diabetology
Hôtel-Dieu, Paris, France
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Citation
Roger Assan, Jean R Attali, Giuseppe Ballerio, Josette Boillot, Jean R Girard; Glucagon Secretion Induced by Natural and Artificial Amino Acids in the Perfused Rat Pancreas. Diabetes 1 April 1977; 26 (4): 300–307. https://doi.org/10.2337/diab.26.4.300
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