In order to clarify the physiologic role of somatostatin in insulin release, rat pancreatic islets treated by somatostatin antiserum were incubated in media containing various concentrations of glucose. Insulin release from antiserum-treated islets was significantly elevated above that from nontreated ones at 3.3 and 8.3 mM glucose, while the former was not different from the latter at 16.7 mM glucose. It is suggested that somatostatin plays an important role in the regulation of insulin release in the physiologic range of glucose concentration.
Physiologic Role of Somatostatin Insulin Release from Rat Islets Treated by Somatostatin Antiserum
Hiroshi Taniguchi, Masafumi Utsumi, Masami Hasegawa, Tetsuo Kobayashi, Youzo Watanabe, Keiji Murakami, Michio Seki, Akimitsu Tsutou, Hiroyuki Makimura, Masahiro Sakoda, Shigeaki Baba; Physiologic Role of Somatostatin Insulin Release from Rat Islets Treated by Somatostatin Antiserum. Diabetes 1 July 1977; 26 (7): 700–702. https://doi.org/10.2337/diab.26.7.700
Download citation file: