Dogs were made alioxan-diabetic and randomly distributed into either of two prospective treatment groups. In one group it was intended that the metabolic signs of diabetes be controlled poorly, and commercial insulin was administered in doses inadequate to prevent chronic, severe hyperglycemie and glucosuria. In the other group it was intended that the metabolic disorder be well controlled, and the animals received food and commercial insulin twice daily such that the hyperglycemie and glucosuria became mild or infrequent. Experimental improvement of the carbohydrate disorder was accompanied by amelioration of hyperUpemia and other clinical signs of deficient insulin activity. By 60 months of diabetes, retinal capillary aneurysms, pericyte ghosts, obliterated vessels, and other microvascular abnormalities typical of diabetes were apparent In each animal of the poor-control group. Better control was found to reduce significantly the incidence and severity of microvascular lesions. The data suggest that the mechanism responsible for diabetic retinopathy is initiated as a result of deficient insulin activity and that the development of the microvascular complications of diabetes are preventable and may be inhibited by careful control of the metabolic disorder.
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Original Contributions| August 01 1977
Relationship of Microvascular Disease in Diabetes to Metabolic Control
Ronald Engerman, PhD;
J M B Bloodworth, Jr, MD;
Address reprint requests to Dr. Ronald Engerman, Department of Ophthalmology, University of Wisconsin, 1300 University Avenue, Madison, Wisconsin 53706.
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Ronald Engerman, J M B Bloodworth, Susan Nelson; Relationship of Microvascular Disease in Diabetes to Metabolic Control. Diabetes 1 August 1977; 26 (8): 760–769. https://doi.org/10.2337/diab.26.8.760
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