Normal subjects and patients with adult-onset diabetes received 10 gm. of aspirin in four days. On the fourth day, the fasting serum glucose and the glucose response to oral glucose were decreased in both groups. These changes were associated with increased levels of serum insulin and pancreatic glucagon, although the glucagon responses to oral glucose were unchanged. In the diabetic patients, aspirin therapy was followed by a decreased glucose response to I.V. glucose and by the appearance of an early insulin peak, which could not be demonstrated before treatment. Aspirin did not affect the I.V. glucose tolerance in normal subjects, although it did enhance the early insulin peak. A decrease in the fasting levels of free fatty acids was noted in both groups, whereas the fasting level of triglycerides decreased only in the diabetic patients. Cholesterolemia did not change in either group. A few preliminary observations indicate that, in normal subjects, ibuprofen and ketoprofen, two other presumed prostaglandin inhibitors, did not affect fasting glycemia, glucose tolerance, or the insulin response to glucose. No changes were noted after the administration of placebo.
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Original Contributions|
December 01 1978
Aspirin Stimulates Insulin and Glucagon Secretion and Increases Glucose Tolerance in Normal and Diabetic Subjects
Piero Micossi, MD;
Piero Micossi, MD
Department of Research, Sinai Hospital of Detroit and the Department of Physiology, Wayne State University School of Medicine
Detroit, Michigan
Cattedra di Terapia Medica, Università degli Studi di Milano
Ospedale L. Sacco, 20157 Milan, Italy
Cattedra di Patologia Medica, Università degli Studi di Milano
Ospedale S. Raffaele, 20090 Milan-Segrate, Italy
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Antonio E Pontiroli, MD;
Antonio E Pontiroli, MD
Department of Research, Sinai Hospital of Detroit and the Department of Physiology, Wayne State University School of Medicine
Detroit, Michigan
Cattedra di Terapia Medica, Università degli Studi di Milano
Ospedale L. Sacco, 20157 Milan, Italy
Cattedra di Patologia Medica, Università degli Studi di Milano
Ospedale S. Raffaele, 20090 Milan-Segrate, Italy
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Steven H Baron, MD;
Steven H Baron, MD
Department of Research, Sinai Hospital of Detroit and the Department of Physiology, Wayne State University School of Medicine
Detroit, Michigan
Cattedra di Terapia Medica, Università degli Studi di Milano
Ospedale L. Sacco, 20157 Milan, Italy
Cattedra di Patologia Medica, Università degli Studi di Milano
Ospedale S. Raffaele, 20090 Milan-Segrate, Italy
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Raul C Tamayo, MD;
Raul C Tamayo, MD
Department of Research, Sinai Hospital of Detroit and the Department of Physiology, Wayne State University School of Medicine
Detroit, Michigan
Cattedra di Terapia Medica, Università degli Studi di Milano
Ospedale L. Sacco, 20157 Milan, Italy
Cattedra di Patologia Medica, Università degli Studi di Milano
Ospedale S. Raffaele, 20090 Milan-Segrate, Italy
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Frieda Lengel;
Frieda Lengel
Department of Research, Sinai Hospital of Detroit and the Department of Physiology, Wayne State University School of Medicine
Detroit, Michigan
Cattedra di Terapia Medica, Università degli Studi di Milano
Ospedale L. Sacco, 20157 Milan, Italy
Cattedra di Patologia Medica, Università degli Studi di Milano
Ospedale S. Raffaele, 20090 Milan-Segrate, Italy
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Maurizio Bevilacqua, MD;
Maurizio Bevilacqua, MD
Department of Research, Sinai Hospital of Detroit and the Department of Physiology, Wayne State University School of Medicine
Detroit, Michigan
Cattedra di Terapia Medica, Università degli Studi di Milano
Ospedale L. Sacco, 20157 Milan, Italy
Cattedra di Patologia Medica, Università degli Studi di Milano
Ospedale S. Raffaele, 20090 Milan-Segrate, Italy
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Umberto Raggi, MD;
Umberto Raggi, MD
Department of Research, Sinai Hospital of Detroit and the Department of Physiology, Wayne State University School of Medicine
Detroit, Michigan
Cattedra di Terapia Medica, Università degli Studi di Milano
Ospedale L. Sacco, 20157 Milan, Italy
Cattedra di Patologia Medica, Università degli Studi di Milano
Ospedale S. Raffaele, 20090 Milan-Segrate, Italy
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Guido Norbiato, MD;
Guido Norbiato, MD
Department of Research, Sinai Hospital of Detroit and the Department of Physiology, Wayne State University School of Medicine
Detroit, Michigan
Cattedra di Terapia Medica, Università degli Studi di Milano
Ospedale L. Sacco, 20157 Milan, Italy
Cattedra di Patologia Medica, Università degli Studi di Milano
Ospedale S. Raffaele, 20090 Milan-Segrate, Italy
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Piero P Foà, MD,PhD
Piero P Foà, MD,PhD
Department of Research, Sinai Hospital of Detroit and the Department of Physiology, Wayne State University School of Medicine
Detroit, Michigan
Cattedra di Terapia Medica, Università degli Studi di Milano
Ospedale L. Sacco, 20157 Milan, Italy
Cattedra di Patologia Medica, Università degli Studi di Milano
Ospedale S. Raffaele, 20090 Milan-Segrate, Italy
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Address reprint requests to Dr. P. P. Foà, Department of Research, Sinai Hospital of Detroit, 6767 West Outer Drive, Detroit, Michigan 48235.
Citation
Piero Micossi, Antonio E Pontiroli, Steven H Baron, Raul C Tamayo, Frieda Lengel, Maurizio Bevilacqua, Umberto Raggi, Guido Norbiato, Piero P Foà; Aspirin Stimulates Insulin and Glucagon Secretion and Increases Glucose Tolerance in Normal and Diabetic Subjects. Diabetes 1 December 1978; 27 (12): 1196–1204. https://doi.org/10.2337/diab.27.12.1196
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