The Intranasal application of an Insulin solution in dogs resulted in the rise of plasma immunoreactive insulin and in dose-dependent hypoglycemie. The absorption of insulin from this site was found to be enhanced when insulin was dissolved in an acid medium. In addition, when an insulin preparation with some surfactant was used, the effectiveness of nasally administered insulin was 25 to 30 per cent of that achieved with intravenously administered insulin.
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Original Contributions| March 01 1978
Nasal Absorption of Insulin in Dogs
Shinichiro Hirai, BSc;
Toshiaki Ikenaga, BSc;
Shinichiro Hirai, Toshiaki Ikenaga, Tai Matsuzawa; Nasal Absorption of Insulin in Dogs. Diabetes 1 March 1978; 27 (3): 296–299. https://doi.org/10.2337/diab.27.3.296
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