We have previously shown that adipocytes from adult (between four and five months old) rats have reduced glucagon binding and glucagon-stimulated lipolytic activity when compared with cells from young (1.5 months old) animals. In the present study we measured specific [125I] glucagon binding by purified liver plasma membranes isolated from young and adult rats. When expressed on the basis of membrane protein content, 5'-nucleotidase activity, or specific [125I] insulin binding, the extent of [125I]glucagon binding by liver membranes was not influenced by aging. Furthermore, the degree of [125I] glucagon degradation was the same in both membrane preparations. These data describe a unique condition in which glucagon binding and hormone sensitivity diminish in one tissue but remain unaltered in another.
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Brief Notes and Comments| May 01 1978
[125I] Glucagon Binding by Liver Membranes from Young and Adult Rats
Dean H Lockwood, MD;
Address reprint requests to Dean H. Lockwood, M.D., Department of Medicine, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, New York 14642.
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Dean H Lockwood, L Elizabeth East; [125I] Glucagon Binding by Liver Membranes from Young and Adult Rats. Diabetes 1 May 1978; 27 (5): 589–591. https://doi.org/10.2337/diab.27.5.589
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