Synthetic Fragment of Human Growth Hormone with Hyperglycemic Properties: Residues 44–77

Peptides homologous to Cys⁵³ 44–77 and Cys⁵³ 52–77 of the human growth hormone molecule were prepared by solid-phase synthesis and tested by our acute glucose tolerance test in ob/ob mice. Peptide 44–77, as either the Acm-Cys⁵³ or Cam-Cys⁵³ derivative, adversely affects glucose tolerance at doses of 100 to 150 nmol. Peptide 52–77 is nonhyperglycemic. Other diabetogenic properties are being tested.