Intravenous somatostatin boluses produced striking diminution in portal vein blood flow in dogs (maximally 40–55%). This effect was of rapid onset, without observable changes in hepatic artery flow, systemic blood pressure, pulse or central venous pressure. The duration of action was short, but could be sustained by continuous intravenous infusion. These observations are consistent with an endocrine role of somatostatin in the regulation of nutrient balance.
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Original Contributions| October 01 1979
Reduction in Portal Vein Blood Flow by Somatostatin
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Jonathan Jaspan, Kenneth Polonsky, Michael Lewis, A Rahim Moossa; Reduction in Portal Vein Blood Flow by Somatostatin. Diabetes 1 October 1979; 28 (10): 888–892. https://doi.org/10.2337/diab.28.10.888
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