Glycosylated hemoglobin (HbA1) concentrations were determined in 300 Pima Indians aged 15 yr and older. Frequency distributions of HbA, were unimodal in the 15-24-yr-old age group, but were bimodal in those aged 25 yr and over. The bimodality indicated that the subpopulation with diabetes could be identified by the presence of elevated HbA1 levels. This group was comprised primarily of subjects who also had fasting plasma glucose levels of < 140 mg/dl, but subjects with impaired glucose tolerance without fasting hyperglycemia had HbA1 levels that were not significantly higher than those with normal glucose tolerance. The prevalence of diabetic retinopathy was much higher in the subgroup with elevated HbA1 levels and increased with increasing HbA1 level. HbA1 levels and triglyceride concentrations showed only a modest association. HbA1 determinations provided no advantage over fasting or post challenge glucose levels in the diagnosis Of diabetes.
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November 01 1979
Bimodality of Glycosylated Hemoglobin Distribution in Pima Indians: Relationship to Fasting Hyperglycemia
Eunice V Flock;
Eunice V Flock
Phoenix Clinical Research Section and the Southwestern Field Studies Section, National Institute of Arthritis, Metabolism and Digestive Diseases
Phoenix, Arizona
Case Western Reserve University
Cleveland, Ohio
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Peter H Bennett;
Peter H Bennett
Phoenix Clinical Research Section and the Southwestern Field Studies Section, National Institute of Arthritis, Metabolism and Digestive Diseases
Phoenix, Arizona
Case Western Reserve University
Cleveland, Ohio
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Peter J Savage;
Peter J Savage
Phoenix Clinical Research Section and the Southwestern Field Studies Section, National Institute of Arthritis, Metabolism and Digestive Diseases
Phoenix, Arizona
Case Western Reserve University
Cleveland, Ohio
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Caryll J Webner;
Caryll J Webner
Phoenix Clinical Research Section and the Southwestern Field Studies Section, National Institute of Arthritis, Metabolism and Digestive Diseases
Phoenix, Arizona
Case Western Reserve University
Cleveland, Ohio
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Barbara V Howard;
Barbara V Howard
Phoenix Clinical Research Section and the Southwestern Field Studies Section, National Institute of Arthritis, Metabolism and Digestive Diseases
Phoenix, Arizona
Case Western Reserve University
Cleveland, Ohio
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Norman B Rushforth;
Norman B Rushforth
Phoenix Clinical Research Section and the Southwestern Field Studies Section, National Institute of Arthritis, Metabolism and Digestive Diseases
Phoenix, Arizona
Case Western Reserve University
Cleveland, Ohio
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Max Miller
Max Miller
Phoenix Clinical Research Section and the Southwestern Field Studies Section, National Institute of Arthritis, Metabolism and Digestive Diseases
Phoenix, Arizona
Case Western Reserve University
Cleveland, Ohio
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1
Dr. Rushforth's address is Department of Biology, Case Western Reserve University, Cleveland, Ohio
Address reprint requests to Dr. Peter H. Bennett, NIAMDD, 1440 East Indian School Road, Phoenix, Arizona 85014.
Citation
Eunice V Flock, Peter H Bennett, Peter J Savage, Caryll J Webner, Barbara V Howard, Norman B Rushforth, Max Miller; Bimodality of Glycosylated Hemoglobin Distribution in Pima Indians: Relationship to Fasting Hyperglycemia. Diabetes 1 November 1979; 28 (11): 984–989. https://doi.org/10.2337/diab.28.11.984
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