Normal and mildly diabetic subjects each have their own “set” of basal plasma glucose and insulin concentrations. Diabetic patients have raised basal plasma glucose, with low-normal basal plasma Cpeptide concentrations. Restoring normal glucose levels in mild diabetes by an insulin infusion further reduces the C-peptide concentration, but both the plasma glucose and the C-peptide return to their “set” level when the insulin is withdrawn. These results accord with the action of beta cells and liver in a negative feedback loop that maintains basal plasma glucose and insulin concentrations.
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Articles| March 01 1979
Maintenance of Basal Plasma Glucose and Insulin Concentrations in Maturity-Onset Diabetes
R R Holman;
Address communications to: Dr. R. C. Turner, Clinical Reader, Department of the Regius Professor of Medicine, Radcliffe Infirmary, Oxford, England.
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R R Holman, R C Turner; Maintenance of Basal Plasma Glucose and Insulin Concentrations in Maturity-Onset Diabetes. Diabetes 1 March 1979; 28 (3): 227–230. https://doi.org/10.2337/diab.28.3.227
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