We examined splanchnic metabolism of alanine in 15 normal males under three sets of conditions: infusion of saline (control studies); infusion of somatostatin (SRIF) (bihormonal deficiency of insulin and glucagon); and infusion of somatostatin plus insulin (selective glucagon deficiency). Net splanchnic alanine uptake (NSAU) remained stable over 2 h during infusion of saline. Infusion of SRIF was associated with a fall in estimated hepatic plasma flow (EHPF) whether or not insulin was infused concomitantly. With SRIF only, arterio-hepatic venous alanine differences increased such that NSAU remained stable over 2 h, despite the fall in EHPF. In contrast, with selective glucagon deficiency, NSAU fell significantly after 2 h, an effect consequent on a fall in EHPF and a delayed fall in arterio-hepatic venous (A-HV) alanine differences. Our studies are compatible with a role for basal glucagon in maintenance of splanchnic extraction of alanine in normal man. However, the SRIF-initiated fall in EHPF may exert an infjuence on A-HV alanine differences independent of changes in pancreatic hormone secretion.
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May 01 1979
Splanchnic Metabolism of Alanine in Intact Man: Effects of Somatostatin and Somatostatin Plus Insulin
David Rabin;
David Rabin
Department of Medicine, Vanderbilt University School of Medicine
Nashville, Tennessee
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G L Mueller;
G L Mueller
Department of Medicine, Vanderbilt University School of Medicine
Nashville, Tennessee
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W W Lacy;
W W Lacy
Department of Medicine, Vanderbilt University School of Medicine
Nashville, Tennessee
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J E Liljenquist
J E Liljenquist
Department of Medicine, Vanderbilt University School of Medicine
Nashville, Tennessee
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Address reprint requests to David Rabin, M.D., Vanderbilt University School of Medicine, Division of Endocrinology, Nashville, Tennessee 37232.
Citation
David Rabin, G L Mueller, W W Lacy, J E Liljenquist; Splanchnic Metabolism of Alanine in Intact Man: Effects of Somatostatin and Somatostatin Plus Insulin. Diabetes 1 May 1979; 28 (5): 486–490. https://doi.org/10.2337/diab.28.5.486
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