Duodenal Contribution to Pancreaticoduodenal Vein Islet Hormones During Stimulation of the Canine Pancreas with Calcium

The possible influence of the duodenum on pancreatic hormones in the pancreaticoduodenal venous effluent of the canine pancreas was studied. The magnitude and dynamics of somatostatin, glucagon, and insulin responses during stimulation with 5 mM calcium were identical whether or not the duodenal remnant was excluded from the perfusion by clamping.

The results indicate that during perfusion with calcium the duodenal remnant is without any significant regulatory or contributory role on pancreatic hormone secretion from the isolated canine pancreas preparation.