The dicarboxylic amino acids, aspartic acid and glutamic acid, at their isoelectric pH, reduced aggregation of insulin solutions in vitro for 16 days during continuous agitation at 37°C. Unprotected insulin solutions, when infused via a 14-day impiantatile infusion device in diabetic Chinese hamsters, controlled plasma glucose levels for only 2 days, followed by escape coincident with insulin aggregation. However, when insulin solutions were protected with glutamic acid, euglycemia was maintained for the 14-day life of the device.
Prevention of Insulin Aggregation by Dicarboxylic Amino Acids During Prolonged Infusion
Dr. Bringer's present address is the Clinique des Maladies Metaboliques et Endocriniennes. Centre Hospitalier et Universitaire de Montpellier, 34059 Montpellier Cedex, France.
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Jacques Bringer, Anneliese Heldt, Gerold M Grodsky; Prevention of Insulin Aggregation by Dicarboxylic Amino Acids During Prolonged Infusion. Diabetes 1 January 1981; 30 (1): 83–85. https://doi.org/10.2337/diab.30.1.83
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