Small amounts of donor strain ACI blood injected in conjunction with minimal ALS therapy prolonged islet allograft survival in Wistar-Lewis, diabetic recipients from a mean of 8 days in nontransfused rats to a mean of more than 100 days. ACI skin grafts transplanted on long-surviving transplant-improved rats were rejected within 8 days, which suggested that “classical” tolerance was probably not the mechanism responsible for the blood-induced suppression of islet allograft rejection.
The Effect of Donor Strain Blood and ALS Therapy on Pancreatic Islet Allograft Survival in the Rat
Helena P Selawry, Howard L Cohen, Mei Mei Mui; The Effect of Donor Strain Blood and ALS Therapy on Pancreatic Islet Allograft Survival in the Rat. Diabetes 1 November 1981; 30 (11): 947–950. https://doi.org/10.2337/diab.30.11.947
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