When female eels, fasting and sexually mature, were progressively adapted to cold water (2–4°C), their blood sugar concentration rose to values averaging 600 mg/dl. Control eels, kept in warm water (18–20°C), had a mean blood sugar concentration of 100 mg/dl. After a period of 5–6 mo, the blood capillaries of the rete mirabile in the swimbladder were examined in both control, low blood sugar eels, and in coldadapted, high blood sugar eels. In the latter, the basal laminae of the capillaries were thickened; their amino acids composition was altered and the in vitro glucose carbon incorporation into basal laminae glycoproteins was increased over a wide range of medium glucose concentrations. Furthermore, the diffusion capacity of the rete, as rqeasured with tracer molecules during steady-state conditions in a countercurrent perfusion system, was increased in the hyperglycemic eel. It is concluded that chronic hyperglycemia in the cold-adapted eel is associated with a microangiopathy characterized by morphologic, biochemical, and functional alterations.
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Original contribution|
April 01 1981
Hyperglycemia and Microangiopathy in the Eel
Moise Bendayan;
Moise Bendayan
Departments of Anatomy and Medicine, Université de Montréal, School of Medicine
Montreal, Quebec
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Eugenio A Rasio
Eugenio A Rasio
Departments of Anatomy and Medicine, Université de Montréal, School of Medicine
Montreal, Quebec
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Address reprint requests to Dr. E. Rasio, Metabolic Unit, Notre Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec, H2L4K8, Canada.
Diabetes 1981;30(4):317–325
Article history
Received:
July 19 1979
Revision Received:
November 17 1980
Accepted:
November 17 1980
PubMed:
7202864
Citation
Moise Bendayan, Eugenio A Rasio; Hyperglycemia and Microangiopathy in the Eel. Diabetes 1 April 1981; 30 (4): 317–325. https://doi.org/10.2337/diab.30.4.317
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