The basal plasma insulin and glucose concentrations of 12 diet-treated maturity-onset diabetics were measured at minute intervals for 2 h. Brief, irregular oscillations (mean period 8.8 min) in plasma insulin were superimposed on longer term fluctuations (> 30 min). Time series analysis demonstrated a synchronous plasma glucose oscillation (mean amplitude 0.03 mmol/L) associated with short insulin cycles. The glucose changes seen in diabetic subjects were similar to the short plasma insulin cycles (< 10 min) observed in normal subjects. In contrast, the longer plasma insulin cycles (> 10 min) of normal subjects were associated with a plasma glucose oscillation that rose before the end of the cycle. The demonstration of insulin oscillations independent of preceding plasma glucose changes in both normal and diabetic subjects suggests a pancreatic oscillating mechanism or “pacemaker.” The associated glucose changes may reflect the entrainment, by the insulin cycles, of glucose production or utilization.
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Original contribution| May 01 1981
Brief, Irregular Oscillations of Basal Plasma Insulin and Glucose Concentrations in Diabetic Man
D A Lang;
D R Matthews;
Address reprint requests to Dr. R. C. Turner at the above address.
D A Lang, D R Matthews, M Burnett, R C Turner; Brief, Irregular Oscillations of Basal Plasma Insulin and Glucose Concentrations in Diabetic Man. Diabetes 1 May 1981; 30 (5): 435–439. https://doi.org/10.2337/diab.30.5.435
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