The effect of dietary vitamin E on the synthesis of platelet thromboxane A2 (TxA2) and vascular prostacyclin (PGI2) in streptozotocin-induced diabetic rats was investigated. Thrombin-induced platelet TxA2 synthesis in diabetic rats was significantly elevated, whereas no significant difference was found with collagen-induced synthesis. Arterial PGI2 production was significantly decreased in diabetic rats. Serum lipid peroxide levels were elevated, and platelet vitamin E levels decreased in diabetic rats. When the diabetic rats were maintained on a high vitamin E diet for 2-3 mo, thrombin-induced platelet TxA2, vascular PGI2, and lipid peroxides were restored to levels found in nondiabetic rats. Platelets from diabetic rats maintained on a high vitamin E diet synthesized significantly less collagen-induced TxA2 than platelets from nondietary vitamin E-supplemented diabetic rats or nondiabetic controls.
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Original Contributions|
November 01 1982
Restoration of Prostacyclin/Thromboxane A2 Balance in the Diabetic Rat: Influence of Dietary Vitamin E
C W Karpen;
C W Karpen
Department of Physiological Chemistry, Ohio State University
Columbus, Ohio
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K A Pritchard, Jr;
K A Pritchard, Jr
Department of Physiological Chemistry, Ohio State University
Columbus, Ohio
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J H Arnold;
J H Arnold
Department of Physiological Chemistry, Ohio State University
Columbus, Ohio
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D G Cornwell;
D G Cornwell
Department of Physiological Chemistry, Ohio State University
Columbus, Ohio
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R V Panganamala
R V Panganamala
Department of Physiological Chemistry, Ohio State University
Columbus, Ohio
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Address reprint requests to Dr. Rao V. Panganamala, Department of Physiological Chemistry, Ohio State University, 5170 Graves Hall, 333 West 10th Avenue, Columbus, Ohio 43210.
Diabetes 1982;31(11):947–951
Article history
Received:
March 29 1982
Revision Received:
June 17 1982
Citation
C W Karpen, K A Pritchard, J H Arnold, D G Cornwell, R V Panganamala; Restoration of Prostacyclin/Thromboxane A2 Balance in the Diabetic Rat: Influence of Dietary Vitamin E. Diabetes 1 November 1982; 31 (11): 947–951. https://doi.org/10.2337/diacare.31.11.947
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