The effect of dietary vitamin E on the synthesis of platelet thromboxane A2 (TxA2) and vascular prostacyclin (PGI2) in streptozotocin-induced diabetic rats was investigated. Thrombin-induced platelet TxA2 synthesis in diabetic rats was significantly elevated, whereas no significant difference was found with collagen-induced synthesis. Arterial PGI2 production was significantly decreased in diabetic rats. Serum lipid peroxide levels were elevated, and platelet vitamin E levels decreased in diabetic rats. When the diabetic rats were maintained on a high vitamin E diet for 2-3 mo, thrombin-induced platelet TxA2, vascular PGI2, and lipid peroxides were restored to levels found in nondiabetic rats. Platelets from diabetic rats maintained on a high vitamin E diet synthesized significantly less collagen-induced TxA2 than platelets from nondietary vitamin E-supplemented diabetic rats or nondiabetic controls.
Restoration of Prostacyclin/Thromboxane A2 Balance in the Diabetic Rat: Influence of Dietary Vitamin E
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C W Karpen, K A Pritchard, J H Arnold, D G Cornwell, R V Panganamala; Restoration of Prostacyclin/Thromboxane A2 Balance in the Diabetic Rat: Influence of Dietary Vitamin E. Diabetes 1 November 1982; 31 (11): 947–951. https://doi.org/10.2337/diacare.31.11.947
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