Total RNA extracted from a rat liver cell line (BRL 3A) that synthesizes rat insulin-like growth factor II (IGF-II) was translated in a reticulocyte lysate cell-free system. Incubation of the translation products with antisera to mature rat IGF-II (Mr 8700) selectively immunoprecipitated a Mr 21,600 protein. We propose that this protein represents pre-pro-IGF-II.
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Rapid Publications| July 01 1982
Cell-Free Synthesis of Rat Insulin-like Growth Factor II
Angela Maria Acquaviva;
Carmelo Bruno Bruni;
S Peter Nissley;
Address reprint requests to Dr. Matthew M. Rechler, National Institutes of Health, Building 4, Rm. B1-14, Bethesda, Maryland 20205.
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Angela Maria Acquaviva, Carmelo Bruno Bruni, S Peter Nissley, Matthew M Rechler; Cell-Free Synthesis of Rat Insulin-like Growth Factor II. Diabetes 1 July 1982; 31 (7): 656–658. https://doi.org/10.2337/diab.31.7.656
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