Proximal motor neuropathy is a well-recognized neuropathic complication in human diabetes mellitus, due to microvasculopathic changes. Spontaneously diabetic BB-Wistar rats maintained at a moderate severity of diabetes developed structural proximal motor neuropathy after long-standing diabetes. This was caused by multiple infarcts in the spinal ventral roots. Endoneurial Vessels showed occlusions by platelet aggregates and unstriated fibrin, indicative of a hypercoagulability.
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