The BioBreeding/Worcester (BB/W) rat is a model of spontaneous autoimmune diabetes mellitus and lymphocytic thyroiditis. Additional features supporting an immunologic pathogenesis of the BB/W syndrome include the protective action of antilymphocyte serum, neonatal bone marrow transfusions, and neonatal thymectomy. To evaluate other manifestations of immune dysregulation, the BB/W colony was surveyed for the presence of autoantibodies to a variety of tissue and cell constituents. Anti-smooth muscle and anti-thyroid colloid antibodies were present with great frequency in diabetic animals as well as in normoglycemic offspring of diabetic parents. Anti-parietal cell antibodies were less frequent and islet cell cytoplasmic and adrenal antibodies were not detected. These data suggest that the underlying defect in the BB/W rat is more likely to be an abnormal immune regulatory system than antigenically altered target tissues (“altered self”) under attack by a normal immune surveillance system.
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Original contribution| September 01 1982
Autoantibodies in the BB/W Rat
A A Like;
M C Appel;
Address reprint requests to Dr. Arthur A. Like, Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01605.
A A Like, M C Appel, A A Rossini; Autoantibodies in the BB/W Rat. Diabetes 1 September 1982; 31 (9): 816–820. https://doi.org/10.2337/diab.31.9.816
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