Studies with mice on the survival of skin grafts incompatible with respect to the histocompatibiiity-Y transplantation antigen or to skin-specific antigens, as well as studies with rats on the fate of cultured parathyroid allografts, provide evidence for major histocompatibility restriction in transplantation immunity. If confirmed, these studies indicate that islet allografts devoid of passenger leukocytes might survive better in major histocompatibility complex incompatible recipients.

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