Vasoactive intestinal polypeptide (VIP) has been demonstrated by immunofluorescence histochermistry in nerves in human and rat penile tissue. A reduction in VIP-like immunoreactivity in nerves was revealed in tissue from streptozotocin-diabetic rats and a human diabetic with impotence. These results suggest that an impairment in the VIP-ergic innervation in penile tissue may be an important factor in the development of impotence in diabetes. They also support the view that the streptozotocin-treated rat is a useful experimental model for diabetic autonomie neuropathy.
Vasoactive Intestinal Polypeptide-like Immunoreactive Nerves in Diabetic Penis: A Comparison Between Streptozotocin-treated Rats and Man
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R Crowe, J Lincoln, P F Blacklay, J P Pryor, J S P Lumley, G Burnstock; Vasoactive Intestinal Polypeptide-like Immunoreactive Nerves in Diabetic Penis: A Comparison Between Streptozotocin-treated Rats and Man. Diabetes 1 November 1983; 32 (11): 1075–1077. https://doi.org/10.2337/diab.32.11.1075
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