Experiments were performed on 12-wk-old nonobese diabetic (NOD) mice to investigate the immunologic background of the condition, using ICR mice as controls. The results indicate the following: (1) absolute decreases in number of T lymphocytes, (2) depression of natural killer activity, (3) normal responsiveness in delayed type hypersensitivity and functional depression of killer T cells against allogeneic tumors, (4) diminished resistance to herpes virus infection, and (5) enhanced production of polyclonal antibodies to T cell-dependent antigens. These features are similar to those noted in other autoimmune diseases of man and in their experimental models in laboratory animals. Elucidation of the pathogenetic mechanism of autoimmune diabetes mellitus in NOD mice, therefore, may contribute to the diagnosis, treatment, and prevention of a wide variety of autoimmune diseases.
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Original Contributions|
March 01 1983
Immunologic Aspects of the Nonobese Diabetic (NOD) Mouse: Abnormalities of Cellular Immunity
Shigeki Kataoka;
Shigeki Kataoka
Third Department of Medicine, Tohoku University School of Medicine
Seiryo-Machi, Sendai, Japan
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Jo Satoh;
Jo Satoh
Third Department of Medicine, Tohoku University School of Medicine
Seiryo-Machi, Sendai, Japan
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Hiroshi Fujiya;
Hiroshi Fujiya
Third Department of Medicine, Tohoku University School of Medicine
Seiryo-Machi, Sendai, Japan
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Takayoshi Toyota;
Takayoshi Toyota
Third Department of Medicine, Tohoku University School of Medicine
Seiryo-Machi, Sendai, Japan
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Ryuji Suzuki;
Ryuji Suzuki
Department of Microbiology, Tohoku University School of Dentistry
Seiryo-Machi, Sendai, Japan
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Kyogo Itoh;
Kyogo Itoh
Department of Microbiology, Tohoku University School of Dentistry
Seiryo-Machi, Sendai, Japan
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Katsuo Kumagai
Katsuo Kumagai
Department of Microbiology, Tohoku University School of Dentistry
Seiryo-Machi, Sendai, Japan
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Address reprint requests to Shigeki Kataoka, M.D., Third Department of Medicine, Tohoku University School of Medicine, Seiryo-Machi, Sendai, Japan.
Diabetes 1983;32(3):247–253
Article history
Received:
June 23 1982
Revision Received:
October 11 1982
PubMed:
6298042
Citation
Shigeki Kataoka, Jo Satoh, Hiroshi Fujiya, Takayoshi Toyota, Ryuji Suzuki, Kyogo Itoh, Katsuo Kumagai; Immunologic Aspects of the Nonobese Diabetic (NOD) Mouse: Abnormalities of Cellular Immunity. Diabetes 1 March 1983; 32 (3): 247–253. https://doi.org/10.2337/diab.32.3.247
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