The effect of sustained insulin-induced hypoglycemia on peripheral nerve function and structure was examined in rats. After a period of hypoglycemia (<2.5 mmol/L) of at least 72 h, axonal degeneration and reduction of the maximal amplitude of the evoked muscle action potential occurred, the two abnormalities being correlated negatively (r = −0.99, 2P = 0.00097). One of five rats developed paresis of both hindlegs as well as nerve damage and perikaryal alterations of lower motor neurons.
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Rapid Publications| April 01 1983
Peripheral Neuropathy in Rats Induced by Insulin Treatment
Address reprint requests to Per Sidenius, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus C, Denmark.
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Per Sidenius, Johannes Jakobsen; Peripheral Neuropathy in Rats Induced by Insulin Treatment. Diabetes 1 April 1983; 32 (4): 383–386. https://doi.org/10.2337/diab.32.4.383
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