Plasma insulin, proinsulin, and C-peptide responses to 25 g glucose orally and intravenously administered were measured in 10 healthy males. Plasma insulin response was higher during the oral load in accordance with the “incretin” concept. However, the actual amountof insulin secreted, as measured by the plasma C-peptide response, was similar during the two glucose loads. The higher plasma insulin response after oral glucose was not due to crossreactivity with proinsulin in the insulin assay. These results suggest that the higher plasma insulin response during an oral glucose load is due at least partially to a lower hepatic extraction of insulin.
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Articles| May 01 1983
Discrepancy Between Plasma C-Peptide and Insulin Response to Oral and Intravenous Glucose
Address reprint requests to Sten Madsbad, Department of Surgery I, Kommunehospitalet, DK-1399 Copenhagen K, Denmark.
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Sten Madsbad, Henrik Kehlet, Jannik Hilsted, Bente Tronier; Discrepancy Between Plasma C-Peptide and Insulin Response to Oral and Intravenous Glucose. Diabetes 1 May 1983; 32 (5): 436–438. https://doi.org/10.2337/diab.32.5.436
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