Seven normal volunteers were studied on two different occasions during which 4-h pulsatile (PULS: 0.8 mU · kg−1 · min−1, 7.5 min of 15) and continuous (CONT: 0.4 mU · kg−1 · min1) intravenous (i.v.) infusions of human insulin (Actrapid HM, Novo) were randomly compared. A euglycemic glucose clamp was performed and a 3-3H-glucose infusion was used for determination of endogenous glucose production (EGP) and metabolic clearance rate (MCR) of glucose. Plasma glucose was similar in both conditions; plasma insulin was stable at about 29 mU/L (CONT) and fluctuated between 10 and 45 mU/L (mean: 28, PULS). Exogenous glucose infused was 1.137 ± 0.058 and 1.088 ± 0.099 g · kg−1 · 4h−1 in CONT and PULS, respectively (NS). EGP was totally suppressed in both conditions. Glucose MCR increased similarly to a maximum of 6.71 ± 0.19 (CONT) and 6.79 ± 0.59 (PULS) ml · kg−1 · min−1 during the fourth hour. C-peptide plasma levels remained stable, whereas plasma glucagon, free fatty acids, and 3-hydroxybutyrate were similarly suppressed in both tests. Thus, under these conditions, pulsatile and continuous insulin infusions have similar metabolic effects. These data contrast with those of Matthews et al. (1983) who reported that, at lower plasma concentrations (5–19 mU/L), pulsatile insulin had greater hypoglycemic effect than did continuous delivery. It is concluded that pulsatile insulin shows no greater activity under normoglycemic, moderately hyperinsulinemic conditions in man.
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Original Contributions|
December 01 1984
Similar Metabolic Effects of Pulsatile Versus Continuous Human Insulin Delivery During Euglycemic, Hyperinsulinemic Glucose Clamp in Normal Man
E Verdin;
E Verdin
Divisions of Diabetes and Clinical Pharmacology, Institute of Medicine, University of Liège
Liège, Belgium
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M Castillo;
M Castillo
Divisions of Diabetes and Clinical Pharmacology, Institute of Medicine, University of Liège
Liège, Belgium
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A S Luyckx;
A S Luyckx
Divisions of Diabetes and Clinical Pharmacology, Institute of Medicine, University of Liège
Liège, Belgium
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P J Lefebvre
P J Lefebvre
Divisions of Diabetes and Clinical Pharmacology, Institute of Medicine, University of Liège
Liège, Belgium
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Address reprint requests to Dr. P. J. Lefebvre, Institut de Médecine, Hopital de Bavière, Boulevard de la Constitution, 66, B-4020 Liège, Belgium.
Diabetes 1984;33(12):1169–1174
Article history
Received:
March 06 1984
Revision Received:
May 30 1984
Accepted:
May 30 1984
PubMed:
6389233
Citation
E Verdin, M Castillo, A S Luyckx, P J Lefebvre; Similar Metabolic Effects of Pulsatile Versus Continuous Human Insulin Delivery During Euglycemic, Hyperinsulinemic Glucose Clamp in Normal Man. Diabetes 1 December 1984; 33 (12): 1169–1174. https://doi.org/10.2337/diab.33.12.1169
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