A follow-up study of 1966 patients with insulin-dependent diabetes mellitus (IDDM) who were diagnosed at Children's Hospital of Pittsburgh (CHP) between 1950 and 1981 has been completed. The mean age of the population at follow-up was 21.2 yr with a mean duration of IDDM of 12.9 yr. Nine percent of the patients were deceased, a sevenfold excess in mortality compared with the U.S. population. The relative increase in mortality was greater for females than males and greater for blacks than whites. Before age 20, the primary excess in mortality was at onset of IDDM, or within 6 mo after onset, and was due to acute diabetic complications. After age 20, the annual mortality risk was approximately 2%, which was more than 20 times greater than for the U. S. population. Renal disease was responsible for the majority of these deaths. There was a reduced risk of dying for diabetic patients who were diagnosed between 1966 and 1971 compared with patients diagnosed during earlier years.
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Original Contributions|
March 01 1984
The Pittsburgh Insulin-dependent Diabetes Mellitus (IDDM) Morbidity and Mortality Study: Mortality Results
J S Dorman;
J S Dorman
Department of Epidemiology, Graduate School of Public Health
Pittsburgh, Pennsylvania
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R E Laporte;
R E Laporte
Department of Epidemiology, Graduate School of Public Health
Pittsburgh, Pennsylvania
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L H Kuller;
L H Kuller
Department of Epidemiology, Graduate School of Public Health
Pittsburgh, Pennsylvania
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K J Cruickshanks;
K J Cruickshanks
Department of Epidemiology, Graduate School of Public Health
Pittsburgh, Pennsylvania
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T J Orchard;
T J Orchard
Department of Epidemiology, Graduate School of Public Health
Pittsburgh, Pennsylvania
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D K Wagener;
D K Wagener
Department of Psychiatry, Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania
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D J Becker;
D J Becker
Division of Endocrinology, Department of Pediatrics, Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania
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D E Cavender;
D E Cavender
Department of Epidemiology, Graduate School of Public Health
Pittsburgh, Pennsylvania
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A L Drash
A L Drash
Division of Endocrinology, Department of Pediatrics, Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania
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Address reprint requests to Dr J. S. Dorman, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, DeSoto Street, Pittsburgh, Pennsylvania 15261.
Citation
J S Dorman, R E Laporte, L H Kuller, K J Cruickshanks, T J Orchard, D K Wagener, D J Becker, D E Cavender, A L Drash; The Pittsburgh Insulin-dependent Diabetes Mellitus (IDDM) Morbidity and Mortality Study: Mortality Results. Diabetes 1 March 1984; 33 (3): 271–276. https://doi.org/10.2337/diab.33.3.271
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