The effect of insulin on low-density lipoprotein (LDL) metabolism in vivo was evaluated using the euglycemic insulin clamp technique. In seven subjects, mononuclear cells isolated after a 4-h insulin infusion degraded more 125I-Iabeled LDL than cells isolated after a saline infusion in six control subjects. In addition, insulin caused the accelerated disappearance of 125I-labeled LDL from plasma in subjects previously injected with autologous 125I-LDL. Infusion of saline had no such effect. These data suggest that insulin, in vivo, stimulates LDL catabolism and could thereby influence LDL cholesterol levels. Insulin-induced stimulation of LDL catabolism could account for the reduction of LDL-cholesterol levels observed in intensively treated type I diabetic patients.
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Original Contributions| April 01 1984
In Vivo Stimulation of Low-Density Lipoprotein Degradation by Insulin
Address reprint requests to Dr. Theodore Mazzone, Division of Endocrinology and Metabolism, Michael Reese Medical Center, 29th St. and Ellis Ave., Chicago, Illinois 60616.
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Theodore Mazzone, David Foster, Alan Chait; In Vivo Stimulation of Low-Density Lipoprotein Degradation by Insulin. Diabetes 1 April 1984; 33 (4): 333–338. https://doi.org/10.2337/diab.33.4.333
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