Multiple low-dose injections of streptozotocin (STZ) induce a delayed but progressively increasing state of hyperglycemia in mice. Different inbred strains of mice show different susceptibility to this treatment. We examined whether genetic factors associated with the H-2 complex influence the susceptibility or resistance, using a selected group of 12 inbred and 5 congenie resistant strains of mice. We found that different congenie strains differed significantly in their susceptibility to STZ-induced diabetes, suggesting that H-2-asso-ciated genes do influence the susceptibility. However, at least some inbred strains sharing the same H-2 haplotype also differed in their susceptibility, indicating that genes outside the H-2 complex may also affect the susceptibility. Therefore, there appear to be at least two genes, one within and one or more outside the H-2 complex, that determine the susceptibility to multiple low doses of STZ.
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Original Contributions| June 01 1984
The Influence of Genetic Background on the Susceptibility of Inbred Mice to Streptozotocin-induced Diabetes
Address reprint requests to Dr. Seung-il Shin, Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461.
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Joyce Wolf, Frank Lilly, Seung-Il Shin; The Influence of Genetic Background on the Susceptibility of Inbred Mice to Streptozotocin-induced Diabetes. Diabetes 1 June 1984; 33 (6): 567–571. https://doi.org/10.2337/diab.33.6.567
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