Circulating Immune Complexes and Platelet Thromboxane Synthesis in Patients with Insulin-dependent (Type I) Diabetes Mellitus

Platelets from diabetic subjects with circulating immune complexes (CIC) synthesized greater amounts of thromboxane than did platelets from CIC-negative patients or controls. In view of the known action of CIC on platelet function, a relationship between these two factors may be suggested in the initiation and progression of microangiopathy in diabetes.