Increased glomerular filtration rate and kidney size early in the course of experimental and human diabetes may be important in the pathogenesis of diabetic nephropathy. Factors causing these renal functional changes are unknown. The isolated, perfused rat kidney (IPRK) was used to study the effects of elevated glucose levels on kidneys from normal and diabetic rats in the absence of complex systemic effects of in vivo hyperglycemia. It was found that acute increases in perfusate glucose levels caused sustained dosedependent vasodilatation in both normal and diabetic isolated kidneys. Furthermore, in normal kidneys, raising perfusate glucose to levels seen in moderately severe diabetes caused increased inulin clearance (CIn). In contrast, equal osmolar concentrations of mannitol caused sustained vasoconstriction and a slight decrease in CIn. Prostaglandin synthetase inhibitors reduced glucose-induced vasodilatation by 50% and prevented the increase in CIn that followed the addition of glucose to normal kidneys. Thus, these studies demonstrated that elevated glucose levels caused significant vasodilatation and increased CIn in the IPRK, and these glucose-induced hemodynamic changes were attenuated by prostaglandin synthetase inhibitors. It is possible that these glucose-induced effects may be important determinants of increased glomerular function in early diabetes.
Skip Nav Destination
Article navigation
Original Contributions|
April 01 1985
Glucose-induced Increases in Renal Hemodynamic Function: Possible Modulation by Renal Prostaglandins
Bertram L Kasiske;
Bertram L Kasiske
Nephrology Division, Department of Medicine, Hennepin County Medical Center, University of Minnesota
Minneapolis, Minnesota
Search for other works by this author on:
Michael P O'donnell;
Michael P O'donnell
Nephrology Division, Department of Medicine, Hennepin County Medical Center, University of Minnesota
Minneapolis, Minnesota
Search for other works by this author on:
William F Keane
William F Keane
Nephrology Division, Department of Medicine, Hennepin County Medical Center, University of Minnesota
Minneapolis, Minnesota
Search for other works by this author on:
Address reprint requests to Bertram L. Kasiske, M.D., Regional Kidney Disease Program, 701 Park Avenue, Minneapolis, Minnesota 55415.
Diabetes 1985;34(4):360–364
Article history
Received:
July 17 1984
Revision Received:
October 02 1984
PubMed:
3882500
Citation
Bertram L Kasiske, Michael P O'donnell, William F Keane; Glucose-induced Increases in Renal Hemodynamic Function: Possible Modulation by Renal Prostaglandins. Diabetes 1 April 1985; 34 (4): 360–364. https://doi.org/10.2337/diab.34.4.360
Download citation file:
42
Views