To assess the normality of islet A- and B-cell responses to a nonglucose secretogogue as well as the modulating effect of glucose in NIDDM, we examined plasma C-peptide and glucagonresponses to arginine in eight patients with NIDDM and in six age- and weight-matched nondiabeticvolunteers under conditions of identical hypoglycemia (∼70 mg/dl), euglycemia (94 mg/dl), and hyperglycemia (∼190 mg/dl). Plasma C-peptide responses to glucose and to arginine in the diabetic subjects were both significantly reduced at all glucose concentrations studied (P < 0.01–0.005). The modulating effect of glucose on both islet A- and B-cell responses (slope of relation between plasma Cpeptide or glucagon response versus plasma glucose concentration) was reduced 80% in the diabetic subjects (P < 0.01). We conclude that islet A- and B-cell responses to nonglucose secretogogues are abnormal in patients with NIDDM and that this may result from a functional defect in the modulating effect of glucose on insulin and glucagon secretion, which in some patients may be compensated for by hyperglycemia.
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Original Contribution|
June 01 1985
Abnormal Glucose Modulation of Islet A- and B-Cell Responses to Arginine in Non-insulin-dependent Diabetes Mellitus
George D Dimitriadis;
George D Dimitriadis
Endocrine Research Unit, Departments of Medicine and Physiology, Mayo Medical School and Mayo Clinic
Rochester, Minnesota 55905
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Gregory B Pehling;
Gregory B Pehling
Endocrine Research Unit, Departments of Medicine and Physiology, Mayo Medical School and Mayo Clinic
Rochester, Minnesota 55905
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John E Gerich
John E Gerich
Endocrine Research Unit, Departments of Medicine and Physiology, Mayo Medical School and Mayo Clinic
Rochester, Minnesota 55905
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Address reprint requests to Dr. J E. Gerich at the above address.
Diabetes 1985;34(6):541–547
Article history
Received:
September 14 1984
Revision Received:
December 05 1984
PubMed:
3891467
Citation
George D Dimitriadis, Gregory B Pehling, John E Gerich; Abnormal Glucose Modulation of Islet A- and B-Cell Responses to Arginine in Non-insulin-dependent Diabetes Mellitus. Diabetes 1 June 1985; 34 (6): 541–547. https://doi.org/10.2337/diab.34.6.541
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