The effects on islet hormone secretion of the synthetic replicates of two peptides with potent GH-releasing activity isolated from human pancreatic islet cell tumors (GRF-40 and GRF-44) were studied using the isolated, perfused dog pancreas. GRF-40 produced a dose-dependent stimulation of insulin, glucagon, and somatostatin secretion. The responses to GRF-40 were modified by the prevailing glucose level: higher insulin and somatostatin and lower glucagon responses were obtained at high rather than low glucose. In contrast, GRF-44 did not produce any stimulation of the endocrine pancreas. In vivo GRF-40 and GRF-44 elicited identical pronounced growth hormone responses in the rat. The findings reported here provide support that pancreatic insulin and glucagon are modulated by GRF-40 with somatostatin as its inhibitory counterpart. The question, whether GRF-40 is of physiologic relevance in the regulation of the endocrine pancreas, must await evidence that it is present and releasable from the pancreas.
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January 01 1986
Synthetic Pancreatic Growth Hormone-Releasing Factor (GRF-40) Stimulates the Secretion of the Endocrine Pancreas
Kjeld Hermansen;
Kjeld Hermansen
Second University Clinic of Internal Medicine, and the Institute of Experimental Clinical Research, and the Nordisk Gentofte
DK-2800 Gentofte, Denmark
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Anne Marie Kappelgaard;
Anne Marie Kappelgaard
Second University Clinic of Internal Medicine, and the Institute of Experimental Clinical Research, and the Nordisk Gentofte
DK-2800 Gentofte, Denmark
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Jørgen Esmann;
Jørgen Esmann
Second University Clinic of Internal Medicine, and the Institute of Experimental Clinical Research, and the Nordisk Gentofte
DK-2800 Gentofte, Denmark
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Hans Ørskov
Hans Ørskov
Second University Clinic of Internal Medicine, and the Institute of Experimental Clinical Research, and the Nordisk Gentofte
DK-2800 Gentofte, Denmark
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Address reprint requests to Kjeld Hermansen, M.D., Second University Clinic of Internal Medicine, Kommunehospitalet, DK-8000 Aarhaus C, Sweden.
Diabetes 1986;35(1):119–123
Article history
Received:
July 22 1985
Revision Received:
October 15 1985
PubMed:
2866996
Citation
Kjeld Hermansen, Anne Marie Kappelgaard, Jørgen Esmann, Hans Ørskov; Synthetic Pancreatic Growth Hormone-Releasing Factor (GRF-40) Stimulates the Secretion of the Endocrine Pancreas. Diabetes 1 January 1986; 35 (1): 119–123. https://doi.org/10.2337/diab.35.1.119
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