Decreased glutathione levels in the ocular lens have been invoked as a possible cause for the decreased lenticular Na+-K+-ATPase in diabetes because both are corrected by aldose reductase inhibitors, and the Na+-K+-ATPase is known to be susceptible to oxidation inactivation. Because an analogous Na+-K+-ATPase defect that is prevented by aldose reductase inhibitors has been described in diabetic peripheral nerve, we examined the effect of streptozocin (STZ) diabetes and aldose reductase inhibition on reduced (GSH) and oxidized (GSSG) glutathione levels in crude homogenates of rat sciatic nerve. Neither GSSG nor GSH levels were altered by 2 or 8 wk of untreated diabetes or by aldose reductase inhibition. Because the defect in Na+-K+-ATPase is fully expressed by 4 wk of STZ diabetes, we conclude that altered glutathione redox state plays no detectable role in the pathogenesis of this defect in diabetic peripheral nerve.
Skip Nav Destination
Article navigation
Original Contribution|
November 01 1986
Glutathione Redox State Is Not the Link Between Polyol Pathway Activity and Myo-Inosltol–Related Na+-K+-ATPase Defect in Experimental Diabetic Neuropathy
P B Carroll;
P B Carroll
Diabetes Research Laboratories, Department of Medicine, University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania
Search for other works by this author on:
B M Thornton;
B M Thornton
Diabetes Research Laboratories, Department of Medicine, University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania
Search for other works by this author on:
D A Greene
D A Greene
Diabetes Research Laboratories, Department of Medicine, University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania
Search for other works by this author on:
Address reprint requests to Douglas A. Greene, M.D., Director MDTRC, University of Michigan Hospital, 5510 MSRB #1, Ann Arbor, Ml 48109.
Diabetes 1986;35(11):1282–1285
Article history
Received:
March 14 1986
Revision Received:
June 06 1986
PubMed:
3019809
Citation
P B Carroll, B M Thornton, D A Greene; Glutathione Redox State Is Not the Link Between Polyol Pathway Activity and Myo-Inosltol–Related Na+-K+-ATPase Defect in Experimental Diabetic Neuropathy. Diabetes 1 November 1986; 35 (11): 1282–1285. https://doi.org/10.2337/diab.35.11.1282
Download citation file:
33
Views