Circulating insulin autoantibodies (INSAAb) were measured in discordant monozygotic twins, first-degree relatives, and other groups at “high risk” for the development of insulin-dependent diabetes mellitus (IDDM), and these results correlated with both islet cell antibody (ICAb) status and beta cell function. INSAAb were positive in 31.6% (12 of 38) ICAb-positive subjects but in only 3.1% (3 of 97) ICAb-negative subjects (X2 = 22.4; P < 0.001). Elevated levels of INSAAb tended to correlate with younger age and were observed in individuals irrespective of the prevailing degree of their beta cell function. Eight of 15 subjects detected to be INSAAb positive have thus far progressed to clinical IDDM (X2 = 18.3; P < 0.001). Thus, autoantibodies reactive with the insulin molecule (1) appear to constitute an additional serologie marker of ongoing autoimmunity and development of IDDM, and (2) may reflect heterogeneity in the pathogenesis of IDDM.
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Original Contributions|
February 01 1986
Autoimmunity to Insulin, Beta Cell Dysfunction, and Development of Insulin-dependent Diabetes Mellitus
S Srikanta;
S Srikanta
Research Division, Joslin Diabetes Center, and Department ot Medicine, Brigham and Women's Hospital, New England Deaconess Hospital, Harvard Medical School
Boston, Massachusetts
Diabetes Research Center, Pacific Medical Center, University of Washington
Seattle, Washington
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A T Ricker;
A T Ricker
Research Division, Joslin Diabetes Center, and Department ot Medicine, Brigham and Women's Hospital, New England Deaconess Hospital, Harvard Medical School
Boston, Massachusetts
Diabetes Research Center, Pacific Medical Center, University of Washington
Seattle, Washington
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D K McCulloch;
D K McCulloch
Research Division, Joslin Diabetes Center, and Department ot Medicine, Brigham and Women's Hospital, New England Deaconess Hospital, Harvard Medical School
Boston, Massachusetts
Diabetes Research Center, Pacific Medical Center, University of Washington
Seattle, Washington
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J S Soeldner;
J S Soeldner
Research Division, Joslin Diabetes Center, and Department ot Medicine, Brigham and Women's Hospital, New England Deaconess Hospital, Harvard Medical School
Boston, Massachusetts
Diabetes Research Center, Pacific Medical Center, University of Washington
Seattle, Washington
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G S Eisenbarth;
G S Eisenbarth
Research Division, Joslin Diabetes Center, and Department ot Medicine, Brigham and Women's Hospital, New England Deaconess Hospital, Harvard Medical School
Boston, Massachusetts
Diabetes Research Center, Pacific Medical Center, University of Washington
Seattle, Washington
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J P Palmer
J P Palmer
Research Division, Joslin Diabetes Center, and Department ot Medicine, Brigham and Women's Hospital, New England Deaconess Hospital, Harvard Medical School
Boston, Massachusetts
Diabetes Research Center, Pacific Medical Center, University of Washington
Seattle, Washington
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Address reprint requests to S. Srikanta, M.D., Joslin Diabetes Center, Research Division, One Joslin Place, Boston, Massachusetts 02215.
Diabetes 1986;35(2):139–142
Article history
Received:
July 29 1985
Revision Received:
August 22 1985
PubMed:
3510920
Citation
S Srikanta, A T Ricker, D K McCulloch, J S Soeldner, G S Eisenbarth, J P Palmer; Autoimmunity to Insulin, Beta Cell Dysfunction, and Development of Insulin-dependent Diabetes Mellitus. Diabetes 1 February 1986; 35 (2): 139–142. https://doi.org/10.2337/diab.35.2.139
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