The effect of insulin or glutathione treatment on glutathione content of liver and jejunal mucosa and on superoxide dismutase (SOD) activity of liver, kidney, and erythrocytes was investigated in pair-fed animals with streptozocin (STZ)-induced diabetes. Diabetes lowered hepatic glutathione concentration, but glutathione concentration of the jejunal mucosa was not affected. Insulin, but not oral glutathione, restored hepatic glutathione concentration to normal levels. Diabetes depressed activity of the cytosolic form of SOD in liver, kidney, and erythrocyte. Treatment of diabetic rats with oral glutathione or intramuscular insulin increased cytosolic SOD activity of renal cortex and liver (but not erythrocytes) to control levels. These results suggest a link between glutathione metabolism and cytosolic SOD activity in diabetes.
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Original contribution|
May 01 1986
Effect of Insulin and Oral Glutathione on Glutathione Levels and Superoxide Dismutase Activities in Organs of Rats With Streptozocin-Induced Diabetes
Dean Loven;
Dean Loven
Radiation Research Laboratory, Department of Radiology, of the University of Iowa
Iowa City, Iowa
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Harold Schedl;
Harold Schedl
Veterans Administration Medical Center
Iowa City, Iowa
Department of Internal Medicine, of the University of Iowa
Iowa City, Iowa
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Helen Wilson;
Helen Wilson
Veterans Administration Medical Center
Iowa City, Iowa
Department of Internal Medicine, of the University of Iowa
Iowa City, Iowa
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Tahia T Daabees;
Tahia T Daabees
Department of Pediatrics, of the University of Iowa
Iowa City, Iowa
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Lewis D Stegink;
Lewis D Stegink
Department of Pediatrics, of the University of Iowa
Iowa City, Iowa
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Mary Diekus;
Mary Diekus
Radiation Research Laboratory, Department of Radiology, of the University of Iowa
Iowa City, Iowa
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Larry Oberley
Larry Oberley
Radiation Research Laboratory, Department of Radiology, of the University of Iowa
Iowa City, Iowa
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Address reprint requests to Dr. D. Loven, Radiation, Biology and Oncology, East Carolina University School of Medicine, Greenville, North Carolina 27834.
Diabetes 1986;35(5):503–507
Article history
Received:
July 21 1985
Revision Received:
November 12 1985
PubMed:
3514329
Citation
Dean Loven, Harold Schedl, Helen Wilson, Tahia T Daabees, Lewis D Stegink, Mary Diekus, Larry Oberley; Effect of Insulin and Oral Glutathione on Glutathione Levels and Superoxide Dismutase Activities in Organs of Rats With Streptozocin-Induced Diabetes. Diabetes 1 May 1986; 35 (5): 503–507. https://doi.org/10.2337/diab.35.5.503
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