Rat islets encapsulated in alginate-polylysine membranes were implanted intraperitoneally into nonimmu-nosuppressed streptozocin-induced diabetic mice. Diabetes was reversed within 3 days, and the animals remained normoglycemic for up to 144 days, with a mean xenograft survival of 80 days. This was significantly greater than nonencapsulated islets, which functioned for <14 days. The graft survival rate at 50 days was >80%. Xenografts of rat islets encapsulated in alginate-polyornithine membranes also had a prolonged survival rate. This study demonstrates that encapsulation of pancreatic islets in semipermeable membranes can prolong xenograft survival in the absence of immunosuppreSSion.
This content is only available via PDF.
Copyright © 1986 by the American Diabetes Association