The effects of α2-adrenergic-receptor blocker mianserin on the responses of blood glucose, plasma β- thromboglobulin (β-TG), and various counterregulatory hormones to insulin-induced hypoglycemia were studied in nine healthy male subjects. The α2-adrenoceptor- blocking action of mianserin was confirmed by its inhibitory effect on platelet activation in vitro. Mianserin was given orally 90 min before insulin injection; the same study without mianserin was performed on another day as the control study. The time courses of blood glucose and serum C-peptide (0, 20, 45, and 180 min after the insulin injection) were identical in both studies, indicating that mianserin has no effect on these parameters. However, a significant increase of p-TG at 45 min after insulin injection was completely suppressed by the administration of mianserin (mean ± SE, 68.5 ± 6.0 vs. 28.8 ± 7.6 ng/ml, n = 6, P < .05). No significant differences were obtained between the two studies in the responses of plasma or serum catecholamines, cortisol, glucagon, growth hormone, thromboxane B2, and 6-ketoprostaglandin F1a. These results suggest that epinephrine is responsible for some, if not all, of the β-TG release from the platelets during insulin-induced hypoglycemia.
Skip Nav Destination
Article navigation
Original Contribution|
April 01 1987
Role of α2-Adrenergic Receptor in Platelet Activation During Insulin-Induced Hypoglycemia in Normal Subjects
Hideki Kishikawa;
Hideki Kishikawa
Department of Metabolic Medicine, Kumamoto University Medical School
Honjo, Kumamoto, Japan
Search for other works by this author on:
Haruo Takeda;
Haruo Takeda
Department of Metabolic Medicine, Kumamoto University Medical School
Honjo, Kumamoto, Japan
Search for other works by this author on:
Satoshi Kiyota;
Satoshi Kiyota
Department of Metabolic Medicine, Kumamoto University Medical School
Honjo, Kumamoto, Japan
Search for other works by this author on:
Michiharu Sakakida;
Michiharu Sakakida
Department of Metabolic Medicine, Kumamoto University Medical School
Honjo, Kumamoto, Japan
Search for other works by this author on:
Hideo Fukushima;
Hideo Fukushima
Department of Metabolic Medicine, Kumamoto University Medical School
Honjo, Kumamoto, Japan
Search for other works by this author on:
Kenshi Ichinose;
Kenshi Ichinose
Department of Metabolic Medicine, Kumamoto University Medical School
Honjo, Kumamoto, Japan
Search for other works by this author on:
Hiromi Matsuda;
Hiromi Matsuda
Department of Metabolic Medicine, Kumamoto University Medical School
Honjo, Kumamoto, Japan
Search for other works by this author on:
Nobuhisa Nakamura;
Nobuhisa Nakamura
Department of Metabolic Medicine, Kumamoto University Medical School
Honjo, Kumamoto, Japan
Search for other works by this author on:
Haruo Uzawa
Haruo Uzawa
Department of Metabolic Medicine, Kumamoto University Medical School
Honjo, Kumamoto, Japan
Search for other works by this author on:
Address correspondence and reprint requests to Dr. Hideki Kishikawa, Kumamoto University Medical School, Department of Metabolic Medicine, 1-1-1 Honjo, Kumamoto 860, Japan.
Diabetes 1987;36(4):407–412
Article history
Received:
May 20 1986
Revision Received:
October 15 1986
Accepted:
October 15 1986
PubMed:
3028889
Citation
Hideki Kishikawa, Haruo Takeda, Satoshi Kiyota, Michiharu Sakakida, Hideo Fukushima, Kenshi Ichinose, Hiromi Matsuda, Nobuhisa Nakamura, Haruo Uzawa; Role of α2-Adrenergic Receptor in Platelet Activation During Insulin-Induced Hypoglycemia in Normal Subjects. Diabetes 1 April 1987; 36 (4): 407–412. https://doi.org/10.2337/diab.36.4.407
Download citation file:
42
Views