We analyzed the surface phenotypes of infiltrated cells in pancreases of nonobese diabetic (NOD) mice with monoclonal antibodies to mouse lymphocytes. Most of the infiltrated cells were Thy1+ and Ly1+ T-lymphocytes, and most of them were L3T4+ helper T-lymphocyte subsets. To elucidate the role of L3T4+ T-lymphocytes in the development of insulitis and diabetes in NOD mice, we treated the animals with injections of monoclonal anti-L3T4 antibody. Administration of this antibody prevented the insulitis and diabetes in NOD mice. These results lead to conclusions that the L3T4+ helper T-lymphocytes may play an essential role in the pathogenesis of type I diabetes and that the manipulation of the OKT4+ (Leu3+) T-lymphocyte subset, the human homology of L3T4, with monoclonal antibodies may provide effective therapy for human type I diabetes.
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April 01 1987
Preventive Effect of Monoclonal Anti-L3T4 Antibody on Development of Diabetes in NOD Mice
Takao Koike;
Takao Koike
Second Department of Internal Medicine, the Laboratory Animal Center, Chiba University School of Medicine
Chiba
, and the Department of Pathology, Tokyo Metropolitan Institute of Gerontology
Tokyo, Japan
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Yohjiro Itoh;
Yohjiro Itoh
Second Department of Internal Medicine, the Laboratory Animal Center, Chiba University School of Medicine
Chiba
, and the Department of Pathology, Tokyo Metropolitan Institute of Gerontology
Tokyo, Japan
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Tatsuko Ishii;
Tatsuko Ishii
Second Department of Internal Medicine, the Laboratory Animal Center, Chiba University School of Medicine
Chiba
, and the Department of Pathology, Tokyo Metropolitan Institute of Gerontology
Tokyo, Japan
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Isao Ito;
Isao Ito
Second Department of Internal Medicine, the Laboratory Animal Center, Chiba University School of Medicine
Chiba
, and the Department of Pathology, Tokyo Metropolitan Institute of Gerontology
Tokyo, Japan
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Katsuhiko Takabayashi;
Katsuhiko Takabayashi
Second Department of Internal Medicine, the Laboratory Animal Center, Chiba University School of Medicine
Chiba
, and the Department of Pathology, Tokyo Metropolitan Institute of Gerontology
Tokyo, Japan
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Naoki Maruyama;
Naoki Maruyama
Second Department of Internal Medicine, the Laboratory Animal Center, Chiba University School of Medicine
Chiba
, and the Department of Pathology, Tokyo Metropolitan Institute of Gerontology
Tokyo, Japan
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Hisao Tomioka;
Hisao Tomioka
Second Department of Internal Medicine, the Laboratory Animal Center, Chiba University School of Medicine
Chiba
, and the Department of Pathology, Tokyo Metropolitan Institute of Gerontology
Tokyo, Japan
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Sho Yoshida
Sho Yoshida
Second Department of Internal Medicine, the Laboratory Animal Center, Chiba University School of Medicine
Chiba
, and the Department of Pathology, Tokyo Metropolitan Institute of Gerontology
Tokyo, Japan
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Address correspondence and reprint requests to Takao Koike, MD, Second Department of Internal Medicine, Chiba University School of Medicine, 1-8-1 Inohana, Chiba 280, Japan.
Diabetes 1987;36(4):539–541
Article history
Received:
November 21 1986
Revision Received:
December 30 1986
Accepted:
December 30 1986
PubMed:
3102302
Citation
Takao Koike, Yohjiro Itoh, Tatsuko Ishii, Isao Ito, Katsuhiko Takabayashi, Naoki Maruyama, Hisao Tomioka, Sho Yoshida; Preventive Effect of Monoclonal Anti-L3T4 Antibody on Development of Diabetes in NOD Mice. Diabetes 1 April 1987; 36 (4): 539–541. https://doi.org/10.2337/diab.36.4.539
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